Utility of the affected sib pair method to detect linkage of a sex-linked dominant disease with a sex-linked recessive trait

✍ Scribed by Ranajit Chakraborty

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 304 KB
• Volume: 6
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370060149

✦ Synopsis

Use of affected sib-pairs for linkage determination of a sex-linked dominant disease with a recessive X-chromosome marker will require extremely large sample sizes, particularly when the marker is marginally polymorphic. In addition, this method should not be used without caution on data collected for a traditional LOD score analysis, without considering the parental mating types involved in the informative families. Nevertheless, ascertainment adjustment and correction for dependence of multiple pairs of affected sib-pairs in families suggests that this method provides linkage inference concordant with that of the traditional LOD score analysis.