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Effective Irinotecan (CPT-11)-containing Liposomes: Intraliposomal Conversion to the Active Metabolite SN-38

✍ Scribed by Sadzuka, Yasuyuki ;Hirotsu, Sachiyo ;Hirota, Sadao


Book ID
118699780
Publisher
Wiley (Blackwell Publishing)
Year
1999
Tongue
English
Weight
412 KB
Volume
90
Category
Article
ISSN
0910-5050

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High-performance liquid chromatographic
✍ Nobumitsu Hanioka; Hideto Jinno; Tetsuji Nishimura; Masanori Ando; Shogo Ozawa; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 116 KB πŸ‘ 1 views

## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated