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Effect of α-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues

✍ Scribed by Charles Danzin; Michel J. Jung; Jeffrey Grove; Philippe Bey


Book ID
118938979
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
255 KB
Volume
24
Category
Article
ISSN
0024-3205

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D,L-α-DIFLUOROMETHYLORNITHINE, AN IRREVE
✍ Shailesh Kumar Choudhary; Dipali Sharma; Aparna Dixit 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 171 KB

In the present study, the effect of D,L-alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), on Friend's murine erythroleukemia (MEL) cell differentiation is investigated. DFMO was able to induce differentiation of MEL cells in culture as determined by ha