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Effect of vitreous fluidity on the measurement of blood-retinal barrier permeability using contrast-enhanced MRI

✍ Scribed by Bruce A. Berkowitz; Charles A. Wilson; Paul S. Tofts; Ronald M. Peshock

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
580 KB
Volume
31
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Breakdown of the blood‐retinal barrier (BRB), frequently an early clinical sign in retinopathy, can be accurately determined using contrast‐enhanced MRI. However, increased vitreous fluidity with age and disease may affect the accuracy of the MRI method. We compared the permeability surface area product per area of leaky retina in eyes with normal vitreous (5.42 ± 0.48 × 10^−4^ cm/min, mean ± SEM, n = 5) to the contralateral gas‐compressed vitrectomized eyes (5.41 ± 0.54 × 10^−4^ cm/min, n = 5). The effect of vitrectomy was not significant (P = 0.325) using a Wilcoxon matched pairs signed rank test on the signed differences of the PS' values.

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