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Effect of various liquids on the diffusion of salicylic acid from ointment bases

โœ Scribed by Clyde W. Whitworth

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
324 KB
Volume
57
Category
Article
ISSN
0022-3549

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โœ C. W. Whitworth; A. F. Asker ๐Ÿ“‚ Article ๐Ÿ“… 1974 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 258 KB ๐Ÿ‘ 1 views

The effect of small-scale preparation techniques on the diffusion of salicylic acid from ointment bases was studied. The method of mechanical incorporation of the drug in cold petrolatum base, using a spatula, appeared to result in higher rates of salicylic acid diffusion than those encountered with

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0 Water, alcohol, and dimethyl sulfoxide were each incorporated at 1,2, and 5 concentrations into four ointment bases containing atropine. The diffusion of drug from five samples of each base was determined at 20-min. intervals for 2 hr. The diffusion process was zero order after 20 min. In the majo

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The effect of various starches (corn, potato, rice, arrowroot, and a compressible starch) on the rate of dissolution of salicylic acid from tablets (prepared by double compression) was investigated. Dissolution rate determinations were carried out using three different test methods: USP-NF Method Ty