Effect of small-scale preparation techniques on diffusion of salicylilc acid from various ointment bases

✍ Scribed by C. W. Whitworth; A. F. Asker

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 258 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600631027

✦ Synopsis

The effect of small-scale preparation techniques on the diffusion of salicylic acid from ointment bases was studied. The method of mechanical incorporation of the drug in cold petrolatum base, using a spatula, appeared to result in higher rates of salicylic acid diffusion than those encountered with ointments prepared by fusion, regardless of drug concentration and the presence or absence of a surfactant. A similar effect was produced in the case of a 10% salicylic acid ointment made with a water-in-oil emulsion base.

Keyphrases Ointments-effect of small-scale preparation tech-