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Influence of various starches on dissolution rate of salicylic acid from tablets

✍ Scribed by Thelma W. Underwood; Donald E. Cadwallader

Publisher
John Wiley and Sons
Year
1972
Tongue
English
Weight
442 KB
Volume
61
Category
Article
ISSN
0022-3549

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✦ Synopsis

The effect of various starches (corn, potato, rice, arrowroot, and a compressible starch) on the rate of dissolution of salicylic acid from tablets (prepared by double compression) was investigated. Dissolution rate determinations were carried out using three different test methods: USP-NF Method Types I and I1 and a modified flask method. In all instances, the dissolution of the drdg was fastest from tablets containing a compressible starch, whereas the rank order of the dissolution times of the other starch formulations depended on the dissolution test method. Dissolution rates for starch formulations determined by the stirring agitation-type test methods Were potato > corn > arrowroot > rice, and the rates determined by an 6scillating agitation-type test were corn > rice > arrowroot = potato.

Keyphrases 'J Dissolution rates, salicylic acid tablets-ffect of starch formulation 0 Salicylic acid tablets-ffect of starch excipient on dissolution rate Starches, various, in salicylic acid tabletseffect on dissolution rate

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