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Effect of undernutrition on some enzymes of purine metabolism in different regions of developing rat brain

✍ Scribed by A. Vanella; M. L. Barcellona; M. Avitabile; R. Avola; N. Ragusa; I. Serra; Prof. A. M. Giuffrida

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 450 KB
Volume: 9
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490090210

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✦ Synopsis

The effect of undemutrition on the activity of some enzymes involved in purine metabolism, ie, adenosine aminohydrolase, adenylate aminohydrolase, and inosine phosphorylase in cerebral hemispheres, cerebellum, and brain stem of rats at different days of postnatal development was studied. Adenosine aminohydrolase, adenylate aminohydrolase, and inosine phosphorylase were assayed by radiochemical methods which involve the measurement of the radioactive products formed, ie, inosine, IMP, and hypoxanthine, respectively. The results obtained indicate that undemutrition affects the activity of the enzymes which control the concentration of purine nucleotides to a different degree in the three brain regions examined.

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