𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Studies of the in vitro effect of methylmercury chloride on rat brain neurotransmitter enzymes

✍ Scribed by Mei-Ping Kung; Paul Kostyniak; James Olson; Maureen Malone; Jerome A. Roth

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
293 KB
Volume
7
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

The in vitro effect of methylmercury (MM) on the enzymatic activities of brain cell specific marker enzymes, choline acetyltransferase (CAT), glutamic acid decarboxylase (GAD), 2', 3'-cyclic nucleotide phosphohydrolase (CNP), glutamine synthetase (GS) and enolase was examined. The results demonstrate that at 100 pM MM, GS activity was not affected whereas a small decrease in the activity of both GAD (20%) and enolase (10%) was observed. CNP and CAT activity appeared to be more sensitive toward MM with 100 pM MM producing inhibition of 50% and 30%, respectively. The addition of sulfhydryl protecting reagents such as DTT or sodium thioglycolate can restore the enzyme activities to normal control levels despite prior exposure of the enzymes to MM.

πŸ“œ SIMILAR VOLUMES

In vitro study of microwave effects on c
In vitro study of microwave effects on calcium efflux in rat brain tissue
✍ W. W. Shelton Jr.; J. H. Merritt πŸ“‚ Article πŸ“… 1981 πŸ› John Wiley and Sons 🌐 English βš– 424 KB πŸ‘ 2 views

## Abstract In this study we investigated the prospect of microwave‐induced alteration of ^45^Ca^2+^ efflux from rat neural tissue at low pulse repetition frequencies and low power densities under in vitro conditions. Rat cerebral tissue, preloaded with ^45^Ca^2+^, was exposed to pulsed‐microwave r

Effect of undernutrition on some enzymes
Effect of undernutrition on some enzymes of purine metabolism in different regions of developing rat brain
✍ A. Vanella; M. L. Barcellona; M. Avitabile; R. Avola; N. Ragusa; I. Serra; Prof. πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 450 KB πŸ‘ 1 views

The effect of undemutrition on the activity of some enzymes involved in purine metabolism, ie, adenosine aminohydrolase, adenylate aminohydrolase, and inosine phosphorylase in cerebral hemispheres, cerebellum, and brain stem of rats at different days of postnatal development was studied. Adenosine a

The effect of propazone on the metabolis
The effect of propazone on the metabolism of rat cerebral cortex in vitro
✍ Fuhrman, Frederick A. ;Field, John πŸ“‚ Article πŸ“… 1942 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 453 KB πŸ‘ 2 views

Much information concerning the mechanisms of cell respiration has been obtained through the use of narcotics, such as the barbiturates, urethane and chloretone. These substances in general inhibit respiratory processes and show a certain selectivity of action (cf. Quastel, '39). Recently a new ser

In vivo and in vitro studies on the geno
In vivo and in vitro studies on the genotoxicity of cadmium chloride in mice
✍ Maha A. Fahmy; Fawzia A. E. Aly πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 73 KB πŸ‘ 2 views

The genotoxic effect of cadmium chloride was evaluated in chromosomes of experimental mice using in vivo and in vitro studies. In vivo the induction of micronuclei, sister chromatid exchange in mouse bone marrow and chromosomal aberrations in both somatic and germ cells was investigated. Doses 1.9,

Effects of excitatory amino acid antagon
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro
✍ F. Dorandeu; J. Wetherell; I. Pernot-Marino; J.E.H. Tattersall; P. Fosbraey; G. πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 112 KB πŸ‘ 2 views

Alpha-dendrotoxin (a-DTx), a snake venom toxin which blocks several types of fast-activating voltagedependent potassium channels, induces limbic seizures and neuronal damage when injected into the brain. The mechanisms underlying these convulsant and neuropathological actions are not fully understoo