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Effect of Trichloroethylene and Its Metabolites, Dichloroacetic Acid and Trichloroacetic Acid, on the Methylation and Expression of c-Jun and c-Myc Protooncogenes in Mouse Liver: Prevention by Methionine

✍ Scribed by Tao, L.

Book ID
124155398
Publisher
Oxford University Press
Year
2000
Tongue
English
Weight
341 KB
Volume
54
Category
Article
ISSN
1096-6080

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Trichloroethylene (TCE) is a multimedia environmental pollution that is carcinogenic in mouse liver. The ability of TCE to modulate DNA methylation and the expression of immediate-early protooncogenes was evaluated. Female B6C3F1 mice were administered 1000 mg/kg TCE by gavage 5 days/week and killed