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Effect of tibolone (Org OD14) and its metabolites on aromatase and estrone sulfatase activity in human breast adipose stromal cells and in MCF-7 and T47D breast cancer cells

✍ Scribed by J van de Ven; G.H Donker; M Sprong; M.A Blankenstein; J.H.H Thijssen


Book ID
117668349
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
624 KB
Volume
81
Category
Article
ISSN
0960-0760

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✍ Rosa De Vincenzo; Giovanni Scambia; Pierluigi Benedetti Panici; Andrea Fattoross πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 French βš– 865 KB

In this study the ability of the new pure anti-estrogen IcI 182,780 to modulate the cytotoxic action of adriamycin (ADR) on parental and ADR-resistant MCF-7 (MCF-7 ADRr) human breast-cancer cells was investigated and compared with that of tamoxifen (TAM). TAM enhanced ADR cytotoxicity in MCF-7 ADRr