The reduction of amides with lithium aluminum hydride, aluminum hydride, lithium trimethoxyaluminum hydride, and diborane to the corresponding amines is well known (1).
Effect of the Temperature on the Stoichiometry of Borane Dimethyl Sulfide Reduction of Secondary and Tertiary Amides
β Scribed by Bonnat, M.; Hercouet, A.; Corre, M. Le
- Book ID
- 115517742
- Publisher
- Taylor and Francis Group
- Year
- 1991
- Tongue
- English
- Weight
- 143 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0039-7911
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Selective Reduction of Secondary Amides to Amines in the Presence of Tertiary Amides. -The transformation is achieved by reduction of secondary amide moieties bearing an activating Cbz group with hydrides. Catalytic hydrogenation of the resulting hemiacetals removes the hydroxyl and the Cbz group t
## Abstract The secondary reduction in the direct and oxazaborolidineβcatalyzed asymmetric borane reduction of ketones was investigated by the use of GC/MS tracing titration and control experiments. The results indicate that the secondary reduction affects the enantioselectivity only in noncoordina
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v