Doxorubicin is metabolized extensively to doxorubicinol by the ubiquitous aldoketoreductase enzymes. The extent of conversion to this alcohol metabolite is important since doxorubicinol may be the major contributor to cardiotoxicity. Aldoketoreductases are inhibited in vitro by phenytoin. The presen
โฆ LIBER โฆ
Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice
โ Scribed by Webster, LK; Cosson, EJ; Stokes, KH; Millward, MJ
- Book ID
- 109837348
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 481 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Effect of phenytoin on the pharmacokinet
โ
Barry J. Cusack; Dwaine A. Tesnohlidek; Vicki L. Loseke; Robert E. Vestal; Dean
๐
Article
๐
1988
๐
Springer
๐
English
โ 541 KB
Differential alteration of cisplatin cyt
โ
O.A. Badary; A.B. Abdel-Naim; A.E. Khalifa; F.M.A. Hamada
๐
Article
๐
2000
๐
Springer-Verlag
๐
English
โ 62 KB
Doxorubicin and doxorubicinol pharmacoki
โ
Barry J. Cusack; Stephan P. Young; Joni Driskell; Richard D. Olson
๐
Article
๐
1993
๐
Springer
๐
English
โ 724 KB
A randomized cross-over trial to determi
โ
Sherene Loi; Danny Rischin; Michael Michael; Kally Yuen; Kerrie H. Stokes; Andre
๐
Article
๐
2004
๐
Springer
๐
English
โ 240 KB
Effects of naringin on the pharmacokinet
โ
Sung-Cil Lim; Jun-Shik Choi
๐
Article
๐
2006
๐
John Wiley and Sons
๐
English
โ 96 KB
๐ 2 views
Effect of verapamil on doxorubicin activ
โ
Franca Formelli; Loredana Cleris; Roberto Carsana
๐
Article
๐
1988
๐
Springer
๐
English
โ 763 KB
The effect of the combined administration of verapamil (i.p. twice daily) and doxorubicin (i.v. once weekly) was tested in mice bearing the following: (a) a tumor with induced resistance to doxorubicin (B16VDXR melanoma line); (b) a tumor inherently resistant (MXT mammary carcinoma); and (c) four so