Effect of the G346E Mutation on FGFR3 Activation
โ Scribed by Niphadkar, Nitish
- Book ID
- 122240968
- Publisher
- Biophysical Society
- Year
- 2011
- Tongue
- English
- Weight
- 77 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0006-3495
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## Abstract Mutations in the fibroblast growth factor receptor 3 (__FGFR3__) gene causing constitutive oncogenic protein activation have been shown to be frequent in papillary noninvasive bladder tumours and are associated with a low risk of progression and a favourable outcome. __FGFR3__ alteratio
A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells