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Effect of FGFR3 Juxtamembrane Domain on FGFR3 Dimerization

✍ Scribed by Sarabipour, Sarvenaz; Li, Edwin; Hristova, Kalina


Book ID
122318317
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
37 KB
Volume
100
Category
Article
ISSN
0006-3495

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## Abstract The fibroblast growth factor receptor 3 (FGFR3) is a member of the FGFR subfamily of the receptor tyrosine kinases (RTKs) involved in signaling across the plasma membrane. Generally, ligand binding leads to receptor dimerization and activation. Dimerization involves the transmembrane (T