A G to T mutation at nucleotide position 2128 in the human FGFR3b coding region resulting in a Cys for Gly substitution (G697C) in the tyrosine kinase domain was observed in 62% (44/71) of oral squamous cell carcinomas (OSCC) examined. Immunostained FGFR3b was found in the cytoplasm of prickle cells
Mutational activation of FGFR3: no involvement in the development of renal cell carcinoma
β Scribed by C. G. Stoehr; R. Stoehr; A. Hartmann; F. Hofstaedter; K. Junker; H. Blaszyk; W. F. Wieland; W. Otto; S. Denzinger; B. Walter
- Book ID
- 106124523
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 187 KB
- Volume
- 138
- Category
- Article
- ISSN
- 1432-1335
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