The crude aqueous extract of the microalga Dunaliella tertiolecta was found to have strong inhibitory effects on the aggregation of human platelets induced by thrombin, arachidonic acid and ionomycin. The extraction of the crude aqueous extract with i PrOH and posterior fractionation with solvents o
Effect of the crude extract of Cestrum parqui on carrageenin-induced rat paw oedema and aggregation of human blood platelets
✍ Scribed by Darakhshanda Shehnaz; Faiza Hamid; Fehmida T. Baqai; Viqar Uddin Ahmad
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 51 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
An extract of Cestrum parqui aerial parts in methanol:water (1:1) showed inhibition of carrageenin-induced oedema. The aggregation of human blood platelets induced by adenosine diphosphate and platelet activating factor was also inhibited (IC 50 s were 3 and 2 mg/mL, respectively). On the contrary, the extract did not inhibit arachidonic acid-mediated platelet aggregation.
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Tripterygium wilfordii Hook F (TWH), commonly known as the Thunder-God-Vine, is a popular remedy for rheumatism in southern China. In this study, we investigated the effect of T2 (an extract from TWH) on adjuvant-induced paw oedema in rats and inflammatory mediators. The results showed that an intra