The Antiinflammatory Effect of an Extract of Tripterygium wilfordii Hook F on Adjuvant-induced Paw Oedema in Rats and Inflammatory Mediators Release
✍ Scribed by Chung-Tei Chou
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 89 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
Tripterygium wilfordii Hook F (TWH), commonly known as the Thunder-God-Vine, is a popular remedy for rheumatism in southern China. In this study, we investigated the effect of T2 (an extract from TWH) on adjuvant-induced paw oedema in rats and inflammatory mediators. The results showed that an intraperitoneal injection of T2 could significantly decrease the adjuvant-induced paw oedema of rats. During in vitro study, lipopolysaccharide (LPS)-stimulated human mononuclear prostaglandin E 2 (PGE 2 ) in the culture supernatant was significantly inhibited by T2 at a concentration of 2 g/mL compared with the control group without T2 treatment (22352 ± 4725 vs 43433 ± 9014 pg/mL, p < 0.05). When rat neutrophils were treated with 3 g/mL of T2, the superoxide production was significantly lower than that of the group without T2 treatment (0.72 ± 0.07 vs 1.37 ± 0.04 nmol, p < 0.05). T2 failed to suppress the -glucuronidase release from rat neutrophils but when the concentration was 30 g/mL, it expressed a significant inhibition of lysozyme release (20.7 ± 2.9 vs 38.2 ± 4.0 in the control, p < 0.05). The findings suggest this Chinese herb, like non-steroid antiinflammatory drugs, expresses a potential antiinflammatory effect through its inhibition of PGE 2 and superoxide function and lysozyme release.