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Effect of temperature on the binding of salicylate by human serum albumin

✍ Scribed by John F. Zaroslinski; Steven Keresztes-Nagy; Roland F. Mais; Yvo T. Oester

Book ID
115772238
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
733 KB
Volume
23
Category
Article
ISSN
0006-2952

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## Abstract When drug‐protein binding data are evaluated thermodynamically standard free energy (Ξ”GΒ°), standard enthalpy (Ξ”HΒ°) and standard entropy (Ξ”SΒ°) are usually estimated from association constants __(K__~a~) derived from binding data obtained at only two temperatures. Estimation of Ξ”HΒ° involv