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Effect of substituting fluorine for hydrogen at C-26 and C-27 on the side chain of 1,25-dihydroxyvitamin D3

✍ Scribed by Masaaki Inaba; Senji Okuno; Yoshiki Nishizawa; Yasuo Imanishi; Takashi Katsumata; Itsuro Sugata; Hirotoshi Morii


Book ID
115783283
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
816 KB
Volume
45
Category
Article
ISSN
0006-2952

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Synthesis, Structure, and Biological Act
✍ Dr. Lieve Verlinden; Prof. Annemieke Verstuyf; Dr. Guy Eelen; Prof. Roger Bouill πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 375 KB πŸ‘ 1 views

## Abstract An improved synthetic route to 1Ξ±,25‐dihydroxyvitamin D~3~ des‐side chain analogues **2 a** and **2 b** with substituents at C18 is reported, along with their biological activity. These analogues display significant antiproliferative effects toward MCF‐7 breast cancer cells and prodiffe