𝔖 Bobbio Scriptorium
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Effect of s-triazine compounds on testosterone metabolism in the rat prostate

✍ Scribed by J. Kniewald; V. Osredečki; T. Gojmerac; V. Zechner; Z. Kniewald

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
393 KB
Volume
15
Category
Article
ISSN
0260-437X

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✦ Synopsis

The influence of striazine compounds (atrazine, prometryne and deethylatrazine) on testosterone conversion and Sa-dihydrotestosterone-receptor complex formation was studied in vitro and in vivo in the rat prostate. A marked in vitro influence of atrazine and prometryne (from 0.465 to 1.392 pmol) and their mixtures (in total concentration, 0.928 pmol) on 5a-dihydrotestosterone formation was detected. Sa-Dihydrotestosteronespecific receptor complex formation was inhibited in vitro by ca. 0.5 pmol of atrazine or deethylatrazine and only in vivo by 6 mg of atrazine 100 g-' body wt. daily during 7 days in the prostate cytosol. The inhibition of the enzymic activities responsible for testosterone conversion and steroid hormonereceptor complex formation was non-competitive and reversible, and striazine compounds act as antiandrogens.

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