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Effect of multiple doses of cadmium on glucose metabolism in the rat

✍ Scribed by Dionyssis S. Ithakissios; Wayne V. Kessler; James N. Arvesen; Gordon S. Born

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
394 KB
Volume
63
Category
Article
ISSN
0022-3549

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✦ Synopsis

The effect of multiple doses of cadmium on carbohydrate metabolism in rats was studied. The treated groups received two dose levels, 0.25 and 0.50 mg cadmium/kg ip every 2nd day for 20 doses. Plasma glucose, immunoresponsive insulin levels, and body weights were determined before treatment and after 10 and 20 doses of cadmium. After the last dosage, ~-glucose-l~C (uniformly labeled) was administered to a randomly chosen subgroup and a carbon dioxide radiorespirometry experiment was performed. Statistically significant differences in blood glucose and insulin levels were not detected a t any time, indicating no

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