## Abstract The radioactivity level in blood, bile, urine and contents of parts of the gastroโintestinal tract in rats was studied after subcutaneous administration of ^3^Hโ1,2โdimethylhydrazine (^3^HโSDMH) which induces colonic tumours. The alkylation of DNA, RNA and protein in the intestinal muco
Effect of rhythm of administration of 1,2-dimethylhydrazine on its carcinogenic activity
โ Scribed by K. M. Pozharisskii; V. N. Vokhmyanin; N. A. Kulakov; R. M. Balanski; A. Ya. Likhachev; A. S. Petrov; Ya. D. Shaposhnikov
- Publisher
- Springer US
- Year
- 1978
- Tongue
- English
- Weight
- 696 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0007-4888
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๐ SIMILAR VOLUMES
## Abstract 1,2โdimethylhydrazine (DMH), administered weekly to mice for 20 weeks, induces tumors in the distal segment of colon. Tumors are preceded by enlargement of the mucosal glands resulting from increases in the number of total cells and ^3^Hโthymidine labeled cells/crypt. Cells located in t
## Abstract Administration of dimethylhydrazine (DMH) to adult rats by two subcutaneous injections each of 120 mg(base)/kg body weight and spaced 10 days apart resulted in the development of renal tumours in over 90 per cent. of treated animals at 30 weeks after injection. The tumours were frequent