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Effect of retinoic acid on the spontaneous and interferon-induced activity of human natural killer cells

✍ Scribed by Jochen Abb; Hannelore Abb; Friedrich Deinhardt

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
357 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Non‐toxic concentrations of retinoic acid (RA) inhibited the spontaneous activity of human natural killer (NK) cells. RA also inhibited the activation of human NK cells by treatment with partially purified human leukocyte interferon (HulFNΞ±) or with inducers of IFNΞ± and IFNΞ³. Full expression of the inhibitory action required prolonged exposure of human peripheral blood leukocytes to RA. Implications of these findings for the use of retinoids in the treatment of human malignancies are discussed.

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