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Effect of phosphate concentration in buffered irrigating solutions on arterial thrombosis

✍ Scribed by David M. Brown; Norbert Kania; Laurent A. Lantieri; E. Neil Pasia; Roger K. Khouri

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
244 KB
Volume
16
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

The concentration of phosphate in buffered saline irrigation solutions was evaluated for its effect upon the incidence of arterial thrombosis. A rabbit thrombosis model of combined intimal abrasion and twisted pedicle in the rabbit central ear artery was used. Higher concentrations of phosphate (20 mM) in normal saline yielded a lower thrombosis rate at 7 days postoperatively (50%) in comparison to 5 mM phosphate (89% thrombosis rate; P<0.05). A standard phosphate‐buffered salt solution (Dulbecco's; 9.5 mM phosphate with potassium, calcium, and magnesium salts) also had a high thrombosis rate (91%). This study demonstrates that subtle variations in the irrigation solution can have profound effects upon arterial thrombosis. Β© 1995 Wiley‐Liss, Inc.

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