The effects of chronic partial outflow obstruction in rats were investigated. The urethra of male rats was partially obstructed for 3 or 6 months and bladder function was compared with that of age-matched controls. Bladder function was studied in vivo by infusion cystometry and in vitro by measuring
Effect of partial outflow obstruction on the distribution of free fatty acids and phospholipids in the rabbit bladder
β Scribed by Laura J. O'Connor; Christian W. Goldner; Shirley T. Lau; Martha A. Hass; Robert M. Levin
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 142 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0724-4983
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Bladder outlet obstruction induces severe changes in urinary bladder function and metabolism. These changes are characterized by significant reductions in the ability of the in vitro whole bladder to generate pressure and to empty. Metabolically, partial outlet obstruction induces a shift from oxida
## Abstract ## Aim To determine if tamsulosin treatment prevents or decreases the incidence and severity of outlet obstructionβinduced bladder dysfunction in rabbits. ## Materials and Methods Male New Zealand White rabbits were treated with tamsulosin or vehicle for 4 weeks with treatments initi