Bladder outlet obstruction induces severe changes in urinary bladder function and metabolism. These changes are characterized by significant reductions in the ability of the in vitro whole bladder to generate pressure and to empty. Metabolically, partial outlet obstruction induces a shift from oxida
Effect of urinary bladder outlet obstruction on the rabbit ureter
β Scribed by Jeffery Ruzich; Alan J. Wein; Michael A. Keating; Michael R. Ruggieri; Dr. Robert M. Levin
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 531 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0733-2467
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## Abstract ## Aim To determine if tamsulosin treatment prevents or decreases the incidence and severity of outlet obstructionβinduced bladder dysfunction in rabbits. ## Materials and Methods Male New Zealand White rabbits were treated with tamsulosin or vehicle for 4 weeks with treatments initi
The contractile response of the smooth muscle of the urinary bladder is dependent upon both the entrance of extracellular calcium through receptor-operated calcium channels and the stimulated release of calcium from the sarcoplasmic reticulum. In addition, partial outlet obstruction induces marked a