## Abstract Ochratoxin A (OTA( a nephrotoxic and carcinogenic mycotoxin, was investigated to examine its potency to induce micronuclei (MN) in cultured human lymphocytes. Lymphocyte cultures were treated for the last 48 h with OTA at concentrations of 25 μM, 10 μM, 1 μM, 100 nM, 10 nM, 1 nM, and 10
Effect of ochratoxin A and ochratoxin C on the monocyte and lymphocyte function
✍ Scribed by H. Köhler; M. Heller; W. Erler; G. Müller; H. Rosner; U. Gräfe
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 310 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0178-7888
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The mycotoxin ochratoxin A (OTA) is a chlorinated dihydroisocoumarin derivative connected through an amide-bond to L-phenylalanine. In a previous study we could show that competition with Lphenylalanine-dependent processes does not play a role in OTA neurotoxicity. To test whether the isocoumarin pa
14C-0chratoxin A s obtained by coupling t h e N-hydroxysuccinimide d e r i v a t i v e of t h e l a c t o n e a c i d h y d r o l y s a t e o f n a t u r a l o c h r a t o x i n A w t h 14C-L-8-phenylalanine methylester. 14C-Ochratoxin A inethylester i s converted i n t o 14Gochratox i n A by a l k