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Effect of Mutations and Variations of HLA-A2 on Recognition of a Virus Peptide Epitope by Cytotoxic T Lymphocytes

โœ Scribed by Andrew J. McMichael, Frances M. Gotch, Jesus Santos-Aguado and Jack L. Strominger


Book ID
123636361
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
842 KB
Volume
85
Category
Article
ISSN
0027-8424

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The molecular basis of the recognition of class-I HLA antigens by allo-reactive cytotoxic T lymphocytes (CTL) remains obscure. This article reviews our work in which HLA-B27-specific allo-reactive CTL clones were obtained and their fine specificity was analyzed with a panel of structurally defined H