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Peptide-mediated allo-recognition of HLA-B27 by cytotoxic T lymphocytes

✍ Scribed by Susana Rojo; José A. López de Castro

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
459 KB
Volume
47
Category
Article
ISSN
0020-7136

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✦ Synopsis

The molecular basis of the recognition of class-I HLA antigens by allo-reactive cytotoxic T lymphocytes (CTL) remains obscure. This article reviews our work in which HLA-B27-specific allo-reactive CTL clones were obtained and their fine specificity was analyzed with a panel of structurally defined HLA-B27 natural variants and site-directed mutants expressed on human and mouse cells. The results have implications for the involvement of endogenous peptides in determining the clonal diversity of HLA-B27 allogeneic responses and the fine specificity of T-cell recognition when HLA-B27 is expressed on different cell types.

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