## Background: Recent studies have shown that sex hormones regulate telomerase activity in endometrium and breast tissues. the present study was designed to clarify the effects of androgen on telomerase activity in normal and malignant prostate cells. ## Methods: Androgen-sensitive (lncap) and -i
Effect of modified DNA and RNA oligonucleotides on telomerase activity and tumor cell survival in vitro
β Scribed by L. V. Svinareva; A. I. Glukhov; E. Yu. Moskaleva; V. I. Shvets
- Book ID
- 110152318
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2011
- Tongue
- English
- Weight
- 650 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0003-6838
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## Abstract Ribozyme possesses specific endoribonuclease activity and catalyzes the hydrolysis of specific phosphodiester bonds, which results in the cleavage of target RNA sequences. Here, we evaluated the ability of hammerhead ribozymes targeting human telomerase RNA (hTR) to inhibit the catalyti