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Effects of various agents on DNA fragmentation and telomerase enzyme activities in adenocarcinoma cell lines

✍ Scribed by Didem Turgut Cosan; Ahu Soyocak; Ayse Basaran; İrfan Degirmenci; Hasan Veysi Gunes; Fezan Mutlu Sahin


Publisher
Springer
Year
2010
Tongue
English
Weight
272 KB
Volume
38
Category
Article
ISSN
0301-4851

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The p53 null HL-60 cell line was transfected with plasmids coding for either the wild-type p53 or mutant p53 gene. The stable expression of wild-type p53 resulted in a significant increase in sensitivity to the topoisomerase II poisons etoposide and doxorubicin, but not to the topoisomerase II inhib