Synthesis of (2S)-2-Amino-3-(1H-4-indolyl)propanoic Acid, a Novel Tryptophan Analogue for Structural Modification of Bioactive Peptides. -A new and multigram synthesis of title compound (VIIIa) uses a Schoellkopf chiral auxiliary reagent in the key step. The protected derivative (VIIIb) can be read
Effect of Mobile Phase Composition on Henry’s Constants of 2-Amino-3-phenyl-propanoic Acid, 2-Amino-3-(3-indolyl)-propanoic Acid, and 2-Amino-3-(4-hydroxyphenyl)-propanoic Acid in a Capcell Pak C 18 Chromatography
✍ Scribed by Han, Qiao; Yoo, Chang Geun; Jo, Se-Hee; Yi, Sung Chul; Mun, Sungyong
- Book ID
- 126408575
- Publisher
- American Chemical Society
- Year
- 2008
- Tongue
- English
- Weight
- 877 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0021-9568
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## Abstract A novel chiral stationary phase (CSP) for HPLC was prepared by bonding (__R__)‐1‐phenyl‐2‐(4‐methylphenyl)ethylamine amide derivative of (__S__)‐valine to aminopropyl silica gel through a 2‐amino‐3,5‐dinitro‐1‐carboxamido‐benzene unit. The CSP was used for the separation of some amino a
The preparative separation of the enantiomers of the title compound, a versatile chiral building block for the synthesis of unnatural amino acid esters, by high performance liquid chromatography on a chiral stationary phase (CSP), is reported for the first time. The CSP consists of amylose-(3,5-dime