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ChemInform Abstract: Synthesis of (2S)-2-Amino-3-(1H-4-indolyl)propanoic Acid, a Novel Tryptophan Analogue for Structural Modification of Bioactive Peptides.

✍ Scribed by Abdul H. Fauq; Feng Hong; Bernadette Cusack; Beth M. Tyler; Yuan Ping-Pang; Elliott Richelson

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199922196

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✦ Synopsis

Synthesis of (2S)-2-Amino-3-(1H-4-indolyl)propanoic Acid, a Novel Tryptophan Analogue for Structural Modification of Bioactive Peptides.

-A new and multigram synthesis of title compound (VIIIa) uses a Schoellkopf chiral auxiliary reagent in the key step. The protected derivative (VIIIb) can be readily incorporated into bioactive synthetic peptides.

-(FAUQ,

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