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Effect of malathion on nucleic acid synthesis in phytohemagglutinin-stimulated human lymphocytes

โœ Scribed by A. Czajkowska; Z. Walter

Publisher
Springer
Year
1980
Tongue
English
Weight
528 KB
Volume
56
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

The effect of malathion, an organophosphorus insecticide, on DNA and RNA synthesis was investigated by measuring the rate of incorporation of 3H thymidine and 3H uridine, respectively, into human lymphocytes stimulated by phytohemagglutinin (PHA). Increasing concentrations of malathion, from 10 to 70 micrograms/ml, were added to human lymphocyte cultures at different times in relation to PHA introduction. The lowest applied dose of malathion (10 micrograms/ml) in most cases led to increased incorporation of both 3H thymidine and 3H uridine. Higher concentrations of malathion (30, 50, 70 micrograms/ml) caused a time- and dose-dependent decrease of radioisotope incorporation.

๐Ÿ“œ SIMILAR VOLUMES

Effect of malathion on the genetic mater
Effect of malathion on the genetic material of human lymphocytes stimulated by phytohemagglutinin (PHA)
โœ Z. Walter; A. Czajkowska; K. Lipecka ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Springer ๐ŸŒ English โš– 592 KB

This paper gives the results of studies on the effects of malathion on human lymphocytes stimulated by PHA, including cell survival, chromosomal aberration and nucleic acid content. Increasing malathion doses (10-70 micrograms/ml) were introduced into cultures of human lymphotyes at different times

DNA synthesis and proliferation of human
DNA synthesis and proliferation of human lymphocytes in vitro: III. Fate of cycling cells in aging cultures of phytohemagglutinin stimulated human lymphocytes
โœ John Mendelsohn; Dorothy Hudig; Janice Castagnola ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 813 KB

There are few data available on cell cycle events that occur when proliferation of normal cells in culture is curtailed due to "natural aging" of the culture conditions. Stathmokinetic and cytofluorometry studies were performed on PHA-stimulated human lymphocyte cultures for eight consecutive days.