The effect of malathion, an organophosphorus insecticide, on DNA and RNA synthesis was investigated by measuring the rate of incorporation of 3H thymidine and 3H uridine, respectively, into human lymphocytes stimulated by phytohemagglutinin (PHA). Increasing concentrations of malathion, from 10 to 7
Effect of inhibitors of DNA and protein synthesis on production of mitogenic factor by phytohemagglutinin-stimulated human lymphocytes
โ Scribed by N. N. Voitenok; N. V. Varivotskaya; P. P. Murzenok; N. D. Potemkina
- Publisher
- Springer US
- Year
- 1976
- Tongue
- English
- Weight
- 306 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0007-4888
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This paper gives the results of studies on the effects of malathion on human lymphocytes stimulated by PHA, including cell survival, chromosomal aberration and nucleic acid content. Increasing malathion doses (10-70 micrograms/ml) were introduced into cultures of human lymphotyes at different times
The ability of mouse thymocytes and peripheral blood lymphocytes from rats to synthesize and secrete proteoglycans in the presence of a variety of mitogens and lymphokines was studied in vitro, and it was confirmed that such lymphocytes synthesize and secrete significant quantities of proteoglycans.
There are few data available on cell cycle events that occur when proliferation of normal cells in culture is curtailed due to "natural aging" of the culture conditions. Stathmokinetic and cytofluorometry studies were performed on PHA-stimulated human lymphocyte cultures for eight consecutive days.