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Effect of lipid polarity and cell design on the in vitro transport of salicylic acid

✍ Scribed by Matthew A. Augustine; James Swarbrick

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
438 KB
Volume
59
Category
Article
ISSN
0022-3549

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✦ Synopsis

The transport kinetics of salicylic acid have been studied in a Schulman-type in vitro model cell containing two aqueous phases ( A and C ) separated by a third liquid lipid phase (B) simulating the biomembrane. Prime consideration was given to evaluating the effect of increasing the polarity of the lipid phase on the two forward rate constants, Kl and Kz. While K, ( A 4 B) always increased with increasing polarity of the lipid phase, KI ( B --* C ) was found to increase or decrease depending on the stirring conditions employed in the two aqueous phases. The surfaceto-volume ratio of the immiscible phases was significant in determining the magnitude of the rate constant Kl.

Keyphrases

Salicylic acid-in vitro transport kinetics Lipid phase polarity effect-salicylic acid transport 0 Surface-to-volume ratio, stirring-salicylic acid transport 0 Schulman cell, evaluation -transport studies 0 Partition coefficients, salicylic acid-oilwater phases

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