๐”– Bobbio Scriptorium
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Effect of Ketoconazole on Cyclosporine Dose in Healthy Dogs

โœ Scribed by JOHN DAHLINGER; CLARE GREGORY; JOEL BEA


Book ID
109135909
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
496 KB
Volume
27
Category
Article
ISSN
0161-3499

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The long-term oral ketoconazole (KTZ) treatment extensively inhibits hepatic CYP3A activity. We investigated the effect of the KTZ treatment on hepatic and intestinal extraction of nifedipine (NIF) using beagle dogs. Four dogs were given orally KTZ for 20 days (200 mg, bid). NIF was administered eit