Effect of iodide on total antioxidant status of human serum

✍ Scribed by Rudolf Winkler; Sirid Griebenow; Willibald Wonisch

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 92 KB
• Volume: 18
• Category: Article
• ISSN: 0263-6484
• DOI: 10.1002/(sici)1099-0844(200006)18:2<143::aid-cbf857>3.0.co;2-#

✦ Synopsis

Free radicals and subsequent lipid peroxidation have been implicated in the pathogenesis of several degenerative and chronic diseases which are also treated frequently in spas. There are some data arising from previous studies which support an antioxidant or scavenging eect of iodide, being the essential ingredient of a therapeutically used local brine. The aim of the study was to test the antioxidant capacity of iodide in human serum. For this reason we measured the so-called Total Antioxidant Status determined by a colorimetric method, which re¯ects the protection against the attack of reactive oxygen species, including enzymic and non-enzymic antioxidants. Exogenous iodide applied as NaI, shows a signi®cantly increased antioxidant capacity in comparison with NaCl at a concentration of 15 mM, which is quite comparable to the upper range of serum iodide levels achieved through balneo-therapeutical intervention. This result is in accordance with previous results from in vitro depolymerization experiments with hyaluronic acid. The antioxidant eect of 15 mM NaI has been found to be approaching the physiologically relevant concentration of ascorbic acid (50 mM).