Effect of interferon on synthesis of ssRNA in reovirus type 3-infected L cell cultures
β Scribed by C.J. Gauntt
- Book ID
- 118853670
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- English
- Weight
- 438 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0006-291X
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A persistent latent infection of human embryo fibroblasts by reovirus type 3 was found to be due to the continuous infection of a small proportion of the cells. Superinfection of these cultures by herpes simplex virus resulted in the destruction of the monolayers by the herpes virus without any obvi
## Abstract Interferon inhibits multiplication of murine leukemia L1210 cells and the effect is evident 18 h after subcultivation. At this time a significant decrease in the synthesis of total RNA and protein was observed in interferonβtreated cultures compared to control cultures. Likewise, the fo