In order t o assess the importance of chlorine in a drug molecule as an influence on myeloperoxidase-mediated inflammatory cell functions, the effect of the chlorinated bisphosphonate, clodronate, on human neutrophil chemiluminescence and myeloperoxidase (M PO) activity was compared t o the non-chlo
Effect of indomethacin on human neutrophil chemiluminescence and microbicidal activity
β Scribed by Tim D. Horan; A.A. Noujaim; Thomas A. McPherson
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 518 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0162-3109
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We measured the chemiluminescence (CL) of human neutrophils (PMNLs) exposed to different concentrations of ofloxacin (2, 4, and 6pg/ml) readily achievable in therapy. CL reaction during zymosan phagocytosis by PMNLs obtained from human healthy volunteers was registered in a computer-linked LKB 1251
We have studied an indirect role of serine and thiol proteases in the activation of human neutrophils in vitro. Stimulation was evaluated using a chemiluminescence (CL) generation system. Receptor-dependent and receptor-independent stimuli were studied, e.g. opsonized zymosan, formyl-methionyl-leucy