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The effect of two bisphosphonates on human neutrophil chemiluminescence and myeloperoxidase activity

✍ Scribed by Kowolik, M. J. ;Hyvönen, P. M. ;Sutherland, R. ;Raeburn, J. A.

Publisher
John Wiley and Sons
Year
1991
Weight
342 KB
Volume
6
Category
Article
ISSN
0884-3996

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✦ Synopsis

In order t o assess the importance of chlorine in a drug molecule as an influence on myeloperoxidase-mediated inflammatory cell functions, the effect of the chlorinated bisphosphonate, clodronate, on human neutrophil chemiluminescence and myeloperoxidase (M PO) activity was compared t o the non-chlorinated structural analogue, etidronate. The results suggested that the presence of chlorine may be important t o the enhancement of MPO activity. In addition both drugs manifested low toxicity and both of these observations may have relevance t o host defence.

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