Effect of histamine type 2 receptor antagonist, cimetidine on immune function
β Scribed by A. Aoike; T. Hosokawa; A. Yoshida; N. Marui; K. Nakamura; K. Koyama; Y. Nishi; K. Kawai
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 84 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0192-0561
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The H -antagonists, metiamide and cimetidine were labelled 2 with deuterium and tritium in the 2-position of the imidazole ring by the uncatalyzed exchange reaction with deuterium and tritium oxide at 100Β°C. The sulfur-35 labelled metiamide was prepared by an exchange reaction with elemental sulfur-
Stimulation of central histamine H, and or H, receptors with histaminergic drugs results in a dose-related pressor response and bradycardia in conscious, freely-moving rats. Two recently developed peripheral histamine H, antagonists, MK-208 and BMY-26368, as well as cimetidine, were evaluated with r
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