𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of food restriction of benzo(a)pyrene binding to DNA in wistar rats

✍ Scribed by V. Jagadeesan; K. Krishnaswamy

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
197 KB
Volume
56
Category
Article
ISSN
0300-483X

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Rat liver microsome-mediated binding of
Rat liver microsome-mediated binding of benzo(A)pyrene metabolites to DNA
✍ M. H. Thompson; H. W. S. King; M. R. Osborne; P. Brookes 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 422 KB 👁 1 views

## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8‐dihydro‐7,8‐dihydroxy

The role of 9-hydroxybenzo(a)pyrene in t
The role of 9-hydroxybenzo(a)pyrene in the microsome mediated binding of benzo(a)pyrene to dna
✍ H. W. S. King; M. H. Thompson; P. Brookes 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 523 KB

## Abstract A study of the liver microsome‐mediated binding to added DNA of the phenol metabolites of benzo (a)‐pyrene (BP‐OH) and of 7,8‐dihydro‐7,8‐dihydroxybenzo (a)pyrene (BP‐7,8‐diol) suggested that as in the case of BP itself the reaction was catalysed by the enzyme aryl hydrocarbon hydroxyla

Retention of tritium during the binding
Retention of tritium during the binding of tritiated benzo(a)pyrene to DNA
✍ M. R. Osborne; M. H. Thompson; H. W. S. King; P. Brookes 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 417 KB 👁 1 views

## Abstract Chemical conversion of generally tritiated benzo (a) pyrene to 6 and 1,6‐substituted derivatives resulted in 30% and 48% loss of tritium respectively. Metabolism of [^3^H], [^14^C]‐benzo (a) pyrene by rat liver microsomes yielded 3‐hydroxybenzo (a) pyrene with 30% loss of tritium, a mix

The binding of benzo(a)pyrene to DNA com
The binding of benzo(a)pyrene to DNA components of differing sequence complexity
✍ P. Jack; P. Brookes 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 708 KB

## Abstract An examination has been made of the binding, both __in vitro__ and __in vivo__ of the benzo(__a__)pyrene (BP) adduct to DNA components of differing sequence complexity. Annealing was performed at low renaturation temperatures in the presence of high concentrations of formamide to minimi

The importance of intercalation in the c
The importance of intercalation in the covalent binding of benzo(a)pyrene diol epoxide to DNA
✍ Michael C. MacLeod 📂 Article 📅 1990 🏛 Elsevier Science 🌐 English ⚖ 513 KB

The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac

Excretion of 3-hydroxy-benzo(a)pyrene an
Excretion of 3-hydroxy-benzo(a)pyrene and mutagenicity in rat urine after exposure to benzo(a)pyrene
✍ F. J. Jongeneelen; Ch. M. Leijdekkers; R. P. Bos; J. L. G. Theuws; P. Th. Hender 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 463 KB 👁 1 views

3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a