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Effect of fluoxetine on plasma desipramine and 2-hydroxydesipramine

✍ Scribed by Raymond F. Suckow; Steven P. Roose; Thomas B. Cooper


Book ID
118855672
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
399 KB
Volume
31
Category
Article
ISSN
0006-3223

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The antidepressant fluoxetine (FLU) and its N-demethylated metabolite, norfluoxetine (NFLU), each contains a chiral center. The combination of FLU and desipramine (DMI), another antidepressant, has been reported to be useful in treatment of depression, to dramatically increase plasma levels of DMI a