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The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization

✍ Scribed by Mary-Frances Jett; Jennifer McGuirk; Dan Waligora; John C Hunter


Book ID
117479623
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
449 KB
Volume
69
Category
Article
ISSN
0304-3959

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The antidepressant fluoxetine (FLU) and its N-demethylated metabolite, norfluoxetine (NFLU), each contains a chiral center. The combination of FLU and desipramine (DMI), another antidepressant, has been reported to be useful in treatment of depression, to dramatically increase plasma levels of DMI a