✦ LIBER ✦

Effect of exercise on propranolol pharmacokinetics

✍ Scribed by S. Frank; S. M. Somani; M. Kohnle

Publisher: Springer
Year: 1990
Tongue: English
Weight: 418 KB
Volume: 39
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00315416

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✦ Synopsis

The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects. There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the pharmacokinetics of propranolol, a flow limited drug, is marked but variable. This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.

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