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Effect of erythromycin and itraconazole on the pharmacokinetics of intravenous lignocaine

✍ Scribed by M. H. Isohanni; P. J. Neuvonen; V. J. Palkama; K. T. Olkkola

Publisher
Springer
Year
1998
Tongue
English
Weight
181 KB
Volume
54
Category
Article
ISSN
0031-6970

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The current research evaluated and compared the efficacy of hydroxybutenyl-b-cyclodextrin (HBenBCD) and hydroxypropyl-b-cyclodextrin (HPBCD) as enhancers of itraconazole solubility and oral bioavailability. At 10 wt% cyclodextrin, 17-fold and 3.8-fold increases in itraconazole aqueous solubility wer