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Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

✍ Scribed by Teijo I. Saari; Juha Grönlund; Nora M. Hagelberg; Mikko Neuvonen; Kari Laine; Pertti J. Neuvonen; Klaus T. Olkkola

Publisher
Springer
Year
2010
Tongue
English
Weight
282 KB
Volume
66
Category
Article
ISSN
0031-6970

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Pharmacokinetics of itraconazole after intravenous and oral dosing of itraconazole-cyclodextrin formulations
✍ Charles M. Buchanan; Norma L. Buchanan; Kevin J. Edgar; Sandra Klein; James L. L 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

The current research evaluated and compared the efficacy of hydroxybutenyl-b-cyclodextrin (HBenBCD) and hydroxypropyl-b-cyclodextrin (HPBCD) as enhancers of itraconazole solubility and oral bioavailability. At 10 wt% cyclodextrin, 17-fold and 3.8-fold increases in itraconazole aqueous solubility wer