Effect of cyclosporine on drug transport and pharmacokinetics of nifedipine
โ Scribed by Madhura Dorababu; Asako Nishimura; Thangavelu Prabha; Kazumasa Naruhashi; Nobuyuki Sugioka; Kanji Takada; Nobuhito Shibata
- Book ID
- 116314203
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 247 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0753-3322
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๐ SIMILAR VOLUMES
The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin. On average, the
Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(